Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells.

Abstract

Cell death induced by both paclitaxel and novel taxane SB-T-1216 in breast cancer cells is associated with caspase activation and with the formation of interphase microtubule bundles. Novel taxane SB-T-1216, but not paclitaxel, seems to be capable of inducing cell death without the accumulation of cells in the G(2)/M phase.