Metal‐Free Direct Construction of Sulfonamides <i>via</i> Iodine‐ Mediated Coupling Reaction of Sodium Sulfinates and Amines at Room Temperature

Abstract

Abstract A simple, practical, and metal‐free protocol has been developed for the synthesis of sulfonamides from sodium sulfinates and various amines through an iodine‐mediated SN bond formation reaction at room temperature. This green reaction is cost‐effective, operationally straightforward, and especially proceeds under very mild conditions to afford the target products in good to excellent yields (up to 98%). magnified image