Annals of the New York Academy of Sciences · 1994 · 14 citations · 6 references
Life SciencesCell BiologyEndocrinologyCell SignalingElectrophysiologySignal TransductionCalcium SignalingHormone SecretionIntracellular Calcium SignalingIon Channel PhysiologyIon Channel RegulationNeuroendocrine PhysiologyCalcium Channel FunctionCalcium Ion SignalingCalcium Signaling In Endocrine CellsCalcium-dependent Channel RegulationCalcium-dependent Hormone ReleasePatch-clamp AnalysisVoltage-dependent Ion ChannelsVoltage-gated Calcium Channels
Similar to neuronal cells, neuroendocrine cells express voltage-dependent ion channels and fire action potentials. Ca2+ influx through voltage-dependent Ca2+ channels couples changes in membrane potential to Ca(2+)-dependent cellular processes, such as hormone release. Using the patch-clamp technique, we studied the spontaneous electrical activity as well as voltage-dependent Ca2+ channels in cholecystokinin-producing pancreatic cells (RIN 1056E cell line), in prolactin-secreting pituitary cells (GH3 cell line), and in calcitonin-secreting cells of the thyroid (rMTC 44-2 cell line). All three cell types displayed spontaneous electrical activity, that is, they spontaneously produced action potentials. RIN 1056E cells, GH3 cells, and rMTC cells exhibited (various types of) voltage-dependent Ca2+ channels that were regulated by various neurotransmitters and hormones, such as somatostatin.
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Adi F. Gazdar, William L. Chick, Herbert K. Oie et al. · Proceedings of the National Academy of Sciences · 1980 · 496 citations · Full text
Different β-subunits determine G-protein interaction with transmembrane receptors
Christiane Kleuss, Hans Scherübl, J. Hescheler et al. · Nature · 1992 · 394 citations
Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials
Werner Schlegel, Benoît P. Winiger, Patrice Mollard et al. · Nature · 1987 · 330 citations