Diabetes · 1981 · 57 citations · 9 references
MedicineEndocrinologyPharmacologyBiochemical PharmacologyMucosal Drug DeliveryOral Drug DeliveryDigestive PhysiologyDrug AbsorptionGastrointestinal AbsorptionGastrointestinal PharmacologyGastrointestinal PhysiologyIntestinal AbsorptionGlucose AbsorptionInsulin PhysiologyIntestinal Absorption EnhancementIntestinal Absorption PhysiologyIntestinal Glucose TransportIntestinal Glucose UptakeRectal Drug AbsorptionViscous Effects
Sodium 5-methoxysalicylate, previously shown to enhance the rectal absorption of several drugs, facilitates the absorption of insulin from the upper gastrointestinal tract, resulting in significantly elevated insulin levels and lowered glucose concentrations in the plasma of rats. Restricting the movement of insulin and adjuvant down the intestine by either ligation or use of a more viscous vehicle further increased the absorption of insulin.
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Oral administration of insulin by encapsulation within liposomes
Harish M. Patel, Brenda E. Ryman · FEBS Letters · 1976 · 211 citations
Absorption of Insulin from the Human Small Intestine
Chilton Crane, G. R. W. N. Luntz · Diabetes · 1968 · 59 citations
Medicine, Endocrinology, Surgery +12
Effect of Trypsin Inhibitor on Passage of Insulin Across the Intestinal Barrier
M. Laskowski, Herbert A. Haessler, Ralph P. Miech et al. · Science · 1958 · 58 citations