<i>In vitro</i> and <i>in vivo</i> responses to short‐term recombinant human insulin‐like growth factor‐1 (IGF‐I) in a severely growth‐retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene

Abstract

These studies show evidence in each of the indices examined of in vivo resistance to IGF-I and suggest that the growth retardation observed in such patients may be the direct result of the absence of one of the alleles encoding the type 1 IGF receptor.