Norrin Protected Blood–Brain Barrier Via Frizzled-4/β-Catenin Pathway After Subarachnoid Hemorrhage in Rats

Abstract

Norrin protected blood-brain barrier integrity and improved neurological outcome after SAH, and the action of Norrin appeared mediated by Frizzled-4 receptor activation, which promoted β-catenin nuclear translocation, which then enhanced Occludin, VE-Cadherin, and ZO-1 expression. Norrin might have potential to protect blood-brain barrier after SAH.