Vitamin D Protects Human Endothelial Cells From Oxidative Stress Through the Autophagic and Survival Pathways

Abstract

The present study shows that VitD may prevent endothelial cell death through modulation of the interplay between apoptosis and autophagy. This effect is obtained by inhibiting superoxide anion generation, maintaining mitochondria function and cell viability, activating survival kinases, and inducing NO production.