Concepedia

Publication | Open Access

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

DOIFull Paper Access

166

Citations

28

References

2014

Year

Feng Hu, Omar Dzaye, Alexander Hahn, Yong Yu, Rick Joey Scavetta, Gunnar Dittmar, Adrian Kaczmarek, Kylie R. Dunning, Carmela Ricciardelli, Jan Leo Rinnenthal,
Neuro-Oncology

Abstract

Our results show that versican released from glioma promotes tumor expansion through glioma-associated microglial/macrophage TLR2 signaling and subsequent expression of MT1-MMP. This signaling cascade might be a novel target for glioma therapies.

References

YearCitations

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