Trophic action of sympathetic nerves reduces arterial smooth muscle Ca²⁺sensitivity during early post-natal development in rats

Abstract

Sympathetic denervation reverses developmental changes both in Ca(2+) sensitivity and in the expression of regulatory proteins back to the early post-natal phenotype in the rat saphenous artery. We conclude that trophic effects of sympathetic nerves govern functional remodelling of arteries during early post-natal development.