Intraperitoneal Injection of Thalidomide Attenuates Bone Cancer Pain and Decreases Spinal Tumor Necrosis Factor-α Expression in a Mouse Model

Abstract

These results suggest that thalidomide can efficiently alleviate bone cancer pain and it may be a useful alternative or adjunct therapy for bone cancer pain. Our data also suggest a role of spinal TNF-α in the development of bone cancer pain.