A Short Total Synthesis of the Marine Sponge Pyrrole‐2‐aminoimidazole Alkaloid (±)‐Agelastatin A

Abstract

Ring by ring: (±)-Agelastatin A has been synthesized through the use of domino and one-pot reactions while minimizing protecting group usage. The core was accessed through a stereoselective domino condensation/ring-opening/4π-conrotatory electrocyclization and elaborated using newly developed protocols for urea and amide formation. Oxidation of an unprotected pre-agelastatin A and an intramolecular aza-Michael reaction completed the synthesis in only six steps. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.