Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor <i>Prdx1</i> with Apoptosis Induction in Esophageal Cancer Cells - Concepedia

Concepedia

Publication | Open Access

Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor <i>Prdx1</i> with Apoptosis Induction in Esophageal Cancer Cells

DOI Full Paper Access

55

Citations

31

References

2005

Year

Isamu Hoshino, Hisahiro Matsubara, Naoyuki Hanari, Mikito Mori, Takanori Nishimori, Yasuo Yoneyama, Yasunori Akutsu, Haruhito Sakata, Kazuyuki Matsushita, Naohiko Seki,

Clinical Cancer Research

Abstract

Our results indicate that the antitumor effect of FK228 in esophageal cancer cells is shown at least in part through Prdx1 activation by modulating acetylation of histones in the promoter, resulting in tumor growth inhibition with apoptosis induction.

References

	Year	Citations

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