Total Synthesis of Phoslactomycin B and Its Biosynthetic Deamino Precursor

Abstract

The implicated intermediate in the biosynthesis of phospholine (phoslactomycin B, see picture), namely its deamino precursor, as well as phospholine itself are synthesized. The phoslactomycins show antitumor, antibacterial, and antifungal activities, however, it is not yet known which part of the skeleton contributes to the activities. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600458_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.