Concepedia

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test

Pushpa Sharma, Brandi Benford, ZhaoZ Li, GeoffreySF Ling

Journal of Emergencies Trauma and Shock · 2009 · 64 citations · 17 references

DOIFull text

Open access

Abstract

Lower PDH enzyme levels in blood are related to the global oxidative stress, increased gliosis in brain, and severity of brain injury following TBI. These effects can be prevented by pyruvate through the protection of PDH enzyme and its subunit E-1.

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