Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2 - Concepedia

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Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

183

Citations

23

References

2011

Year

Theo S. Plantinga, Tania O. Crișan, Marije Oosting, Frank L. van de Veerdonk, Dirk J. de Jong, Dana J. Philpott, J.W.M. van der Meer, Stephen E. Girardin, Mihai G. Netea

Abstract

The present study is the first to link the ATG16L1 polymorphism with an excessive production of IL-1β and IL-6 in humans, which may explain the effects of this polymorphism on the inflammatory process in Crohn's disease.

References

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