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Dehydration of Amides to Nitriles Initiated by Hexamethylphosphoric Triamide

Richard S. Monson, Deggary N. Priest

Canadian Journal of Chemistry · 1971 · 14 citations · 1 references

DOI

Concepts

Abstract

Aliphatic and aromatic carboxamides are found to undergo ready dehydration in hexamethylphosphoric triamide at 220–240° affording the corresponding nitriles in good yield.

References

1

The reaction of cycloalkanones with hexamethylphosphoric triamide. an unusual route to 1,2,3,4,5,6,7,8-octahydroacridines.

Richard S. Monson, Deggary N. Priest, James C. Ullrey · Tetrahedron Letters · 1972 · 10 citations

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