Occupancy of Serotonin Transporters by Paroxetine and Citalopram During Treatment of Depression: A [¹¹C]DASB PET Imaging Study

Abstract

During treatment with clinical doses of paroxetine or citalopram, approximately 80% of 5-HTT receptors are occupied. This change in 5-HTT binding potential is greater than the known physiological range of changes in 5-HTT binding potential but may be necessary for some therapeutic effects.