Science · 1994 · 1.4K citations · 21 references
Life SciencesCell BiologyImmunologyCellular ImmunologyImmunoregulationMolecular ImmunologyCytokine BiologyCytokine RegulationImmune Cell SignalingT Cell ActivationT Cell BiologyBiological Activity FeaturesComplementary Dna (Cdna) CloningCytokine-mediated T Cell ActivationCytokine-mediated T Cell ResponsesT Cell Cytokine ProductionT Cell Cytokine SignalingT-cell Activation By Cytokines
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
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Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor
Masayuki Noguchi, Yoshiaki Nakamura, Sarah M. Russell et al. · Science · 1993 · 1.1K citations · Full text
Cloning of the γ Chain of the Human IL-2 Receptor
Toshikazu Takeshita, Hironobu Asao, Kiyoshi Ohtani et al. · Science · 1992 · 843 citations
Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4
Motonari Kondo, Toshikazu Takeshita, Naoto Ishii et al. · Science · 1993 · 728 citations