5‐(Pyrrolidin‐2‐yl)tetrazole‐Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous‐Flow Reactor

Abstract

Continuous organocatalysis: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5-10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 degrees C with reaction times ranging from 10 to 30 min.