Bioinformatics · 2011 · 284 citations · 12 references
Life SciencesBioinformaticsMolecular BiologyGene ExpressionGenomicsTranscriptomicsCancer GenomicsCancer TranscriptomicsDna SequencingGene Fusions In CancerNext-generation SequencingNext-generation Sequencing In OncologyCancer BioinformaticsChimeric Transcript DetectionFusion Gene DiscoveryFusion Transcript AnalysisGene Fusion BioinformaticsNovel Transcript DiscoveryOpen-source Software DevelopmentTranscripts
SUMMARY: Next generation sequencing (NGS) technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts in high-throughput transcriptome sequencing data. AVAILABILITY: http://chimerascan.googlecode.com CONTACT: cmaher@dom.wustl.edu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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