Total Synthesis of Complestatin (Chloropeptin II)

Abstract

Substrate-dependent atropostereoselectivity: Cyclization of a linear DEFG tripeptide by an intramolecular Suzuki–Miyaura reaction afforded the 16-membered DEFG ring with complete atroposelectivity. Intramolecular SNAr reaction of a hexapeptide that contained a prebuilt DEFG ring afforded the bismacrocycle ABCDEFG that was converted to complestatin. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.