Concepedia

Publication | Open Access

Overexpression of S100A4 in human cancer cell lines resistant to methotrexate

DOIFull Paper Access

35

Citations

44

References

2010

Year

Nuria Mencia-Trinchant, Elisabet Selga, Isabel Luis Rico, M. Cristina de Almagro, Xenia Villalobos, Sara Ramírez, Jaume Adán, José Luís Hernández, Verónique Noé, Carlos J. Ciudad
BMC Cancer

Abstract

S100A4 is overexpressed in many MTX-resistant cells. S100A4 overexpression decreases the sensitivity of HT29 colon cancer human cells to MTX, whereas its knockdown causes chemosensitization toward MTX. Both approaches highlight a role for S100A4 in MTX resistance.

References

YearCitations

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