Acetylcholine‐Induced Vasodilation and Reactive Hyperemia Are Not Affected by Acute Cyclo‐Oxygenase Inhibition in Human Skin

Abstract

These data give no support for a contribution of prostaglandins to acetylcholine-induced vasodilation or to reactive hyperemia in the skin microcirculation. In this vascular bed, local anesthesia seems to amplify acetylcholine-induced vasodilation via a prostaglandin-independent mechanism.