Enantioselective Synthesis of Cyanohydrin <i>O</i>‐Phosphates Mediated by the Bifunctional Catalyst Binolam–AlCl

Abstract

(R)- and (S)-binolam–AlCl complexes act as bifunctional catalysts to mediate the enantioselective cyanophosphorylation of aldehydes at room temperature. The resulting chiral cyanohydrin O-phosphates can be reduced to β-aminoalcohols or, when suitably substituted, can be transformed into γ-cyanoallylic alcohols through palladium-catalyzed allylic substitution, without loss of enantiomeric excess (see scheme).