Retracted: Characterization of enhanced antibacterial effects of novel silver nanoparticles

TLDR

The study reports preparing 10–15 nm silver nanoparticles with increased stability and enhanced antibacterial potency. The nanoparticles were synthesized, characterized by TEM, and shown to disrupt bacterial cell integrity and alter phosphotyrosine signaling, thereby inhibiting growth. The nanoparticles exhibited a dose‑dependent antibacterial effect, markedly stronger than previous reports and more effective against gram‑negative than gram‑positive bacteria.

Abstract

In the present study, we report the preparation of silver nanoparticles in the range of 10-15 nm with increased stability and enhanced anti-bacterial potency. The morphology of the nanoparticles was characterized by transmission electron microscopy. The antibacterial effect of silver nanoparticles used in this study was found to be far more potent than that described in the earlier reports. This effect was dose dependent and was more pronounced against gram-negative bacteria than gram-positive organisms. Although bacterial cell lysis could be one of the reasons for the observed antibacterial property, nanoparticles also modulated the phosphotyrosine profile of putative bacterial peptides, which could thus affect bacterial signal transduction and inhibit the growth of the organisms.