Chemistry - A European Journal · 2015 · 23 citations · 53 references
Natural SciencesBiochemistryChemistryCatalysisRedox BiochemistryCatalytic MechanismsRadical ReactionsRedox CatalysisAlkylation ProcessesAlkylation ReactionsCopper CatalysisCopper-catalyzed OxidationCopper-mediated OxidationTransition Metal-catalyzed Synthesis
A copper-catalyzed ketooxygenation of electron-deficient alkenes was developed. This approach combines O-H alkylation, aerobic decarboxylation, and oxygenation in one transformation. Mechanistic investigation of this reaction showed that the copper salt is responsible for both generating the amidoxyl radical and promoting aerobic decarboxylation.
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