The detection and avoidance of false-positive reactions in tests for rubella-specific IgM - Concepedia

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The detection and avoidance of false-positive reactions in tests for rubella-specific IgM

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1976

Year

J Pattison, J E Mace, D. S. Dane

Journal of Medical Microbiology

Medical MicrobiologySerum SpecimensMolecular Diagnostic TechniquesPathogenesisDiagnosisPathologyRubella-specific Igm ActivityMicrobiologyInfection ControlMedicineClinical MicrobiologyRubella-specific IgmFalse-positive ReactionsDiagnostic Microbiology

Abstract

Serum specimens tested for rubella-specific IgM by the haemagglutination-inhibition technique may give false-positive results due to (a) storage at -20 degrees C, (b) bacterial contamination, or (c) inactivation at 56 degrees C. These false-positive reactions can be distinguished from rubella-specific IgM activity by their resistance to 2-ME.