Effect of <i>Rosmarinus Officinalis</i> Extract on some Cardiac Enzymes of Streptozotocin-induced Diabetic Rats

Abstract

The study was undertaken to evaluate the therapeutic efficacy of water extract of <i>Rosmarinus officinalis</i> L. (rosemary) in Streptozotocin (STZ) induced diabetic rats. The effect of extract on serum cardiac enzymes in STZ induced diabetic rat models and normal control rats were determined. Extract was administered orally, to STZ-induced diabetic rats, at a dose of 200 mg / kg body weight/day for 21 days. The fasting blood glucose level of diabetic rats was decreased significantly after treatment with water extract of rosemary. Activities of aspartate transaminase (AST), creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) were recovered significantly in extract treated diabetic group in respect to untreated diabetic group. After the monitoring of CPK and LDH activities in serum, it has been noted that the extract significantly correct the activities of these enzymes in STZ-induced diabetic rat. To assess the antihyperlipidemic activities of this extract, the serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c) and high density lipoprotein cholesterol (HDL-c) were determined. The results of this experiment demonstrated that, there was a significant recovery in the above mentioned biomarkers of lipid profile in treated STZ-induced diabetic rat.