Direct Peptide Lipidation through Thiol–Ene Coupling Enables Rapid Synthesis and Evaluation of Self‐Adjuvanting Vaccine Candidates

Abstract

A radical lipidation: Application of a novel thiol-ene lipidation enables the one-step synthesis of self-adjuvanting antigenic peptides as vaccine candidates. The resultant monoacyl lipopeptides are shown to activate monocytes in a robust manner.