Neurology · 1979 · 110 citations · 0 references
PharmacyNeurologyToxicologyNeuropathologyNeurotoxicologyOccupational ToxicologyArsenic PoisoningArsenic ToxicologyHeavy Metal NeurotoxicityOccupational NeurotoxicologyPeripheral Nervous System ToxicityPeripheral Neuropathy EvaluationArsenic Exposure AssessmentElectrophysiologic EffectsEnvironmental Arsenic ContaminationEnvironmental Arsenic ExposureNerve Conduction VelocityOccupational Arsenic PoisoningOccupational Peripheral NeuropathySmelting
We conducted a double-blind controlled study of individuals exposed to arsenic trioxide in a copper-smelting factory. Subjects fell into three categories of peripheral neuropathy: none, subclinical, and clinical. The subclinical group had no symptoms or signs of numbness or reduced reflexes, but did have reduced nerve conduction velocity and amplitude measurements. Clinical neuropathy groups had signs and symptoms of neuropathy and electrophysiologic abnormalities. The clinical and subclinical groups correlated with increased content of arsenic in urine, hair and nails. The incidence of subclinical and clinical neuropathy was greater in arsenic workers than in unexposed controls.