Tauroursodeoxycholic Acid Preservation of Photoreceptor Structure and Function in the<i>rd10</i>Mouse through Postnatal Day 30

Abstract

TUDCA is efficacious and safe in preserving vision in the rd10 mouse model of RP when treated between P6 and P30. At P30, a developmental stage at which nearly all rods are absent in the rd10 mouse model of RP, TUDCA treatment preserved rod and cone function and greatly preserved overall photoreceptor numbers.