Clinical and Vaccine Immunology · 2008 · 23 citations · 10 references
MedicineClinical SciencesInfectious DiseasesDiagnostic MicrobiologyMolecular DiagnosticsPulmonologyMycobacterial DiagnosticsPulmonary TuberculosisTuberculosis CareTuberculosis DiagnosisTuberculosis Diagnostic TestingActive Pulmonary TuberculosisDiagnostic EfficiencyInterferon Gamma ProductionPulmonary Tuberculosis DiagnosisSputum ExaminationSputum MicroscopySputum Smear MicroscopyTuberculosis Diagnostics
This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >or=0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.
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