A Highly Enantioselective, Pd–TangPhos‐Catalyzed Hydrogenation of <i>N</i>‐Tosylimines

Abstract

A catalyst system composed of Pd(OCOCF3)2 complexed with the electron-donating, rigid chiral diphosphane TangPhos gives excellent enantioselectivities (up to 99 % ee) and conversions (up to >99 %) in the hydrogenation of N-tosylimines 1 (see scheme). A variety of aromatic, aliphatic, and cyclic chiral amines 2 can be prepared by this methodology.