Angewandte Chemie International Edition · 2006 · 529 citations · 45 references
Natural SciencesBiomedical EngineeringOncologyBiomedical ImagingNanobiotechnologyNanomaterialsCancer NanomedicineMagnetic NanomaterialsMagnetic Resonance ImagingNanomedicineNanoparticle DesignPhotothermal TherapyCancer NanotherapyCancer Photothermal TherapyGold NanostructuresMultifunctional NanomaterialsNanomaterials For Photothermal TherapyNanoparticlesTargeted Photothermal TherapyTheranostic Nanomaterials
Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with gold nanoshells embedded with Fe3O4 nanoparticles. The Fe3O4 nanoparticles allow magnetic resonance imaging (MRI) for diagnosis, and the gold nanoshells enable photothermal therapy. By attaching an antibody to the Mag-GNS by a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted.
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