Concepedia

Endothelial Protease Nexin-1 Is a Novel Regulator of A Disintegrin and Metalloproteinase 17 Maturation and Endothelial Protein C Receptor Shedding via Furin Inhibition

Yacine Boulaftali, Déborah François, Laurence Vénisse, Martine Jandrot‐Perrus, Véronique Arocas, Marie‐Christine Bouton

Arteriosclerosis Thrombosis and Vascular Biology · 2013 · 20 citations · 29 references

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Abstract

Our results thus demonstrate an original role of PN-1 as a furin convertase inhibitor, providing new insights for understanding the regulation of endothelial protein C receptor-dependent aPC endothelial protective effects.

References

29

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Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

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Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

David E. Joyce, Larry Gelbert, A Ciaccia et al. · Journal of Biological Chemistry · 2001 · 650 citations · Full text