Concepedia

Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate

Sandra Laner‐Plamberger, Thomas Lener, Doris Schmid, Doris Streif, Tina Salzer, Michaela Öller, Cornelia Hauser‐Kronberger, Thorsten Fischer, Volker R. Jacobs, Katharina Schallmoser,

Journal of Translational Medicine · 2015 · 48 citations · 46 references

DOIFull text

Open access

Abstract

Here, we present an efficient, reproducible and economical method in compliance to good manufacturing practice for the preparation of MSC media avoiding xenogenic components and suitable for clinical studies.

References

46

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

Katarina Le Blanc, Francesco Frassoni, Lynne M. Ball et al. · The Lancet · 2008 · 2.7K citations

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A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

Joshua M. Hare, Jay H. Traverse, Timothy D. Henry et al. · Journal of the American College of Cardiology · 2009 · 1.3K citations · Full text

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Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation

Susan C. Thornton, Stephen N. Mueller, Elliot M. Levine · Science · 1983 · 802 citations

, , +17

Platelet lysates promote mesenchymal stem cell expansion: A safety substitute for animal serum in cell-based therapy applications

Christelle Doucet, Isabelle Ernou, Yizhou Zhang et al. · Journal of Cellular Physiology · 2005 · 679 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Taly R. Spivak-Kroizman, Mark A. Lemmon, John E. Ladbury et al. · Cell · 1994 · 662 citations

, , +11