Infection and Immunity · 2007 · 31 citations · 15 references
DentistryInfectious DiseasesMicrobiologyOral ImmunologyOral MicrobiologyPeriodontal PathogenesisMucosal ImmunopathologyMucosal PathogenesisOral InfectionsOral Microbial PathogenesisOral Microbial VirulenceOral MucosaImmunodominant AntigensMucosal Infection ModelsMurine ModelsOral Mucosal ImmunityOral Mucosal PathogenesisOral PorphyromonasPorphyromonas Species
The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.
15