REVERSAL OF NATURALLY OCCURRING DIABETES IN PRIMATES BY UNMODIFIED ISLET XENOGRAFTS WITHOUT CHRONIC IMMUNOSUPPRESSION1

Abstract

These results represent the first demonstration in nonhuman primates of stable, long-term acceptance of nonencapsulated xenogeneic islets off all immunosuppression, suggesting operational tolerance. The findings have potential implications for islet transplantation as well as improved and more cost-effective therapy for IDDM.