Journal of Geriatric Psychiatry and Neurology · 2014 · 27 citations · 49 references
MedicineGeriatric MedicineNeurologyDementiaGeriatric AssessmentGerontologyAlzheimer DiseaseCognitive AssessmentCognitive ImpairmentComprehensive Geriatric AssessmentDementia DiagnosisFunctional Assessment In Older AdultsAdult Neurocognitive AssessmentAlzheimer's Disease DiagnosisCognitive Impairment EvaluationDaily Functioning AssessmentExtrapyramidal SignsGeriatric Cognitive AssessmentMemory ScoresNeuropsychiatric Assessment In Aging
OBJECTIVE: To examine the diagnostic ability of the Lawton Instrumental Activities Daily Living (IADLs) scale and the Activities Daily Living (ADLs) scale as a sensitive tool to Alzheimer's disease (AD) in community-dwelling elderly people. DESIGN: In an old age memory outpatient center, among patients with a clinical diagnosis of AD dementia or no dementia supported by at least 6 months of follow-up, we looked back at the baseline Lawton IADL scale (short version IADL-4 item), ADL scale, Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MOCA) values. RESULTS: There were 109 patients with AD and 53 nondemented individuals (81.4 ± 4.6 years). The sensitivity of ADL scale or IADL-4 item or the MMSE was low (52%-57%). The most efficient AD classification used both the IADLs-4 item and the MOCA with a threshold score of 20. Besides age and memory scores, the main correlates of IADLs scale or ADLs scale were executive, neuropsychiatric, vascular, and extrapyramidal scores. CONCLUSION: Our results suggest that the Lawton IADLs-4 item scale and ADLs scale lack sensitivity to AD dementia in elderly people and support a better sensitivity of MOCA rather than MMSE and IADLs-4 item/ADLs at the expense of specificity.
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pROC: an open-source package for R and S+ to analyze and compare ROC curves
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