Publication | Closed Access
Proline‐Mediated Enantioselective Construction of Tetrahydropyridines <i>via</i> a Cascade Mannich‐Type/Intramolecular Cyclization Reaction
65
Citations
42
References
2008
Year
Asymmetric CatalysisEngineeringBiochemistryNatural SciencesDiversity-oriented SynthesisP ‐MethoxyphenylOrganic ChemistryEnantioselective ConstructionStereoselective SynthesisChemistryN ‐PmpSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
Abstract A highly diastereo‐ and enantioselective synthesis of 2,3‐disubstituted tetrahydropyridines was accomplished via a proline‐mediated cascade Mannich‐type/intramolecular cyclization reaction from preformed N ‐PMP ( p ‐methoxyphenyl) aldimines and inexpensive aqueous tetrahydro‐2 H ‐pyran‐2,6‐diol.
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