Highly Selective Metal Catalysts for Intermolecular Carbenoid Insertion into Primary CH Bonds and Enantioselective CC Bond Formation

Abstract

Primary CH bond activation! A Rh complex of bis-pocket porphyrin I catalyzes carbenoid insertion into the CH bonds of n-alkanes with a primary/secondary selectivity (per CH bond) of up to 11.4:1 (see picture). Enantioselective secondary CH bond functionalization catalyzed by a Rh complex of Halterman's chiral porphyrin features up to 93 % ee. These reactions exhibit up to 6477 turnovers after the catalyst was recycled five times. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.