Synthesis and anticonvulsant activity of clubbed thiazolidinone–barbituric acid and thiazolidinone–triazole derivatives

Abstract

A new series of clubbed thiazolidinone-barbituric acid and thiazolidinone-triazole derivatives was synthesized to study the effect of a hydrophobic unit, hydrogen bonding domain and electron-donor group on the compounds' anticonvulsant activity. The structures of the synthesized compounds were confirmed by their spectroscopic data and elemental analysis. All compounds were evaluated for their anticonvulsant activity in two animal models of seizures, viz. maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). The compounds were also evaluated for neurotoxicity. Compounds 4g, 4i, 5g and 5i exhibited excellent anticonvulsant activity in both animal models of seizure.