Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: <i>In Vitro</i> Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Abstract

This work provides clinical evidence for the importance of antagonism between Runx2 and E2 signaling in breast cancer. Likely sensing the tension between them, letrozole responsiveness of a genomic node, positively regulated by estradiol and negatively regulated by Runx2 in vitro, best correlated with the clinical efficacy of letrozole treatment.