JNCI Journal of the National Cancer Institute · 1988 · 118 citations · 0 references
MedicineOncologyPathologyGastrointestinal OncologyNeoplasiaTumor PathologyColorectal CancerGastrointestinal NeoplasmsHereditary Cancer SyndromesHereditary Gastrointestinal Cancer SyndromesMalignant NeoplasmsTumor ClassificationColon AdenomaColorectal AdenomasColorectal Cancer PathologyColorectal Cancer PredispositionFamilial Colorectal CancerHereditary Colorectal Cancer SyndromesHereditary Nonpolyposis Colorectal CancerPathologic Gross Findings
We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer.