Excessive Sarcoplasmic/Endoplasmic Reticulum Ca ²⁺ -ATPase Expression Causes Increased Sarcoplasmic Reticulum Ca ²⁺ Uptake but Decreases Myocyte Shortening

Abstract

Moderate SERCA1a gene transfer and expression improve contractility and Ca(2+) cycling. However, higher SERCA1a expression levels can impair myocyte shortening because of higher SERCA activity and Ca2+ buffering.