Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma.

Abstract

These results demonstrate an influence of LTB4 on neutrophil influx and activation in the airway following allergen challenge. Despite this anti-inflammatory effect, there was no measured physiological benefit and this questions the functional role of the neutrophil in the pathophysiology of allergen induced asthma.