Anti-Cancer Agents in Medicinal Chemistry · 2012 · 29 citations · 0 references
MedicineMedicinal ChemistryPharmacologyCancer PharmacologyChemotherapyStructure-activity RelationshipsAnti-inflammatory PharmacologyHeterocyclic ChemistryMedicinal PlantsOncology PharmacologyStructure-activity Relationship AnalysisAnti-inflammatory ActivityAnticancer ActivityAnticancer ChemotherapyHeterocyclic Medicinal ChemistryMedicinal Chemistry ApplicationsMedicinal Heterocycles
A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine. Keywords: Anticancer activity, Anti-inflammatory, 1, 4-benzodiazepines, Myeloperoxidase