Synthesis and use of cyclic peroxides

Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L

Mitchell A. Avery, Wesley K. M. Chong, Clive Jennings-White · Journal of the American Chemical Society · 1992 · 248 citations

Natural Sciences, Chemistry, Pharmacology +10

Mechanism-Based Design, Synthesis, and in vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial Activity

Gary H. Posner, Chang Ho Oh, Dasong Wang et al. · Journal of Medicinal Chemistry · 1994 · 187 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Endoperoxide formation in a guanosine derivative

Chimin Sheu, Christopher S. Foote · Journal of the American Chemical Society · 1993 · 111 citations

Natural Sciences, Chemistry, Pharmacology +6

Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes.

Gary H. Posner, C. H. Oh, L. Gerena et al. · Journal of Medicinal Chemistry · 1992 · 104 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Synthesis, Structure, and Antimalarial Activity of Tricyclic 1,2,4‐Trioxanes Related to Artemisinin

Charles W. Jefford, Javier Velarde, Gérald Bernardinelli et al. · Helvetica Chimica Acta · 1993 · 77 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16