Publication | Open Access
New Regioselective Total Syntheses of Antibiotic Renierol, Renierol Acetate, and Renierol Propionate from the 5-Oxygenated Isoquinoline.
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1999
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Medicinal ChemistryEngineeringRenierol AcetateNatural SciencesNew Total SynthesesOrganic ChemistrySynthetic ChemistryStereoselective SynthesisChemistryHeterocycle Chemistry5-Oxygenated IsoquinolinePharmacologyRenierol PropionateAntibiotic RenierolEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
New total syntheses of renierol (3), renierol acetate (4), and renierol propionate (5) were completed by the synthesis of 5-oxygenated isoquinoline (6) based on the thermal electrocyclic reaction of the 1-azahexatriene system followed by regioselective oxidations of 5-hydroxyisoquinolines (6).