Common Variation in the <i>FTO</i> Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

Abstract

FTO genotype is associated with metabolic traits to an extent entirely consistent with its effect on BMI. Sample sizes of >12,000 individuals were needed to detect associations at P < 0.05. Our findings highlight the importance of using appropriately powered studies to assess the effects of a known diabetes or obesity variant on secondary traits correlated with these conditions.